Drug: pioglitazone

The most common side effects of pioglitazone alone or in combination with sulfonylureas, metformin, or insulin are:
  • upper respiratory tract infection,
  • headache,
  • sinusitis,
  • muscle aches,
  • tooth disorders,
  • hypoglycemia, and
  • sore throat.
In addition, dose related fluid accumulation (edema) can occur especially when combined with insulin. Fluid accumulation can worsen or lead to heart failure. Pioglitazone should not be used in patients with heart disease classified by the New York Heart Association (NYHA) as Class III and IV heart failure or symptomatic heart failure. Fluid accumulation also may lead to macular edema, resulting in reduced vision. Pioglitazone also can reduce red blood cells. Pioglitazone has been associated with liver injury. Periodic monitoring of liver-related side effects and liver tests should be conducted in patients taking pioglitazone.

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Tablets: 15, 30 and 45 mg.

Source: http://www.medicinenet.com

Tablets should be kept at room temperature, 15 C -30 C (59 F -86 F).

Source: http://www.medicinenet.com

Pioglitazone is prescribed once daily in doses ranging from 15 to 45 mg. The recommended starting dose for patients without heart failure is 15 or 30 mg and for those with heart failure it is 15 mg daily. Pioglitazone may be taken any time of the day, with or without meals. If a dose is missed on one day, two doses should not be taken the next day to make up for the missed dose.

Source: http://www.medicinenet.com

There are no adequate studies of pioglitazone in pregnant women. Pioglitazone may be used in pregnancy if the physician feels the potential risks are justified.

Source: http://www.medicinenet.com

It is unknown if pioglitazone is secreted in breast milk. Therefore, the effect of pioglitazone on the nursing infant whose mother is taking pioglitazone is unknown. Medically reviewed by Eni Williams, PharmDREFERENCE: FDA Prescribing Information

Source: http://www.medicinenet.com

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