Autoplex® T, Anti-Inhibitor Coagulant Complex, Heat Treated, is packaged with 30 mL Sterile Water for Injection, USP; a double-ended needle; a filter needle; and a package insert. NDC 59730-6059-7 Storage Autoplex® T, Anti-Inhibitor Coagulant Complex, Heat Treated, should be stored under ordinary refrigeration (2 - 8°C, 36 - 46°F). Avoid freezing to prevent damage to the diluent bottle. References 2. Kurczynski EM, Penner JA: Activated prothrombin concentrate for patients with factor VIII inhibitors. New Eng J Med 291:164-167, 1974 3. Penner JA, Kelly PE: Management of patients with factor VIII or IX inhibitors. Semin Thromb Hemostas 1:386-399, 1975 4. Buchanan GR, Kevy SV: Use of prothrombin complex concentrates in hemophiliacs with inhibitors: Clinical and laboratory studies. Pediatrics 62:767-774, 1978 5. Mannucci PM, Federici F, Vigano S, et al: Multiple dental extractions with a new prothrombin complex concentrate in two patients with factor VIII inhibitors. Thromb Res 15:359-364, 1979 6. Shapiro SS: Antibodies to blood coagulation factors. Clinics in Haematology 8:207-214, 1979 7. Roberts HR: Hemophiliacs with inhibitors: Therapeutic options. New Eng J. Med 305:757-758, 1981 Bibliography Abildgaard CF, Penner JA, Watson-Williams EJ: Anti-Inhibitor Coagulant Complex (Autoplex) for treatment of factor VIII inhibitors in hemophilia. Blood 56:978, 1980 Fekete L F, Holst SL, Peetoom F, et al: “Auto” Factor IX Concentrate: A new therapeutic approach to treatment of hemophilia A patients with inhibitors. Proceedings, 14th International Congress of Haematology. Sao Paulo, Brazil, 1972 Horwith G, Revie DR. Efficacy of viral clearance methods used in the manufacture of activated concentrates: focus on AUTOPLEX® T. Haemophilia 5 (Supple 3): 19, 1999 Kantrowitz JL et al. Early experience with the use of Anti-Inhibitor Coagulant Complex to treat bleeding in hemophiliacs with inhibitors to factor VIII. Clin Ther 9 (4): 405, 1987 Kelly P, Penner JA: Antihemophilic factor inhibitors: Management with prothrombin complex concentrates. JAMA 236:2061, 1976 Lundblad RL et al. Measurement of active coagulation factors in Autoplex® T with colorimetric active site-specific assay technology. Thrombosis and Haemostatsis 80 (5): 3, 1998 Seligsohn U, Kasper CK, Østerud B, et al: Activated factor VII. Presence in factor IX concentrates and persistence in the circulation after infusion. Blood 53:828, 1979 White, GC, Seventeen years' experience with Autoplex®/Autoplex® T (anti-inhibitor coagulant complex, heat treated) : evaluation of inpatients with severe haemophilia A and factor VIII inhibitors at major haemophilia centre. HAEMOPHILIA: Vol. 6, No. 5, 508-512, 2000. Distributed by: Nabi®, Boca Raton, FL 33487 USA. Manufactured by: Baxter Healthcare Corporation, Glendale, CA 91203 USA. FDA rev date: n/a Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.