What are the contraindications of ACAM2000?

There are very few absolute contraindications to this vaccine for those who are at high risk for smallpox. The risk for experiencing serious vaccination complications must be weighed against the risks for experiencing a potentially fatal smallpox infection. See WARNINGS AND PRECAUTIONS for persons who are at higher risk of experiencing serious vaccination complications. Severe Immune Deficiency Severe localized or systemic infection with vaccinia (progressive vaccinia) may occur in persons with weakened immune systems. Individuals with severe immunodeficiency who are not expected to benefit from the vaccine should not receive ACAM2000. These individuals may include individuals who are undergoing bone marrow transplantation or individuals with primary or acquired immunodeficiency who require isolation. Last reviewed on RxList: 9/29/2014
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com