Avoid drinking alcohol. It may increase your risk of stomach bleeding or liver damage while you are taking acetaminophen and aspirin. Ask a doctor before taking acetaminophen if you drink more than 3 alcoholic beverages per day.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as "APAP") and aspirin are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug, which can lead to a fatal overdose. Check the label to see if a medicine contains aspirin, acetaminophen, or APAP.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with acetaminophen and aspirin, especially:
This list is not complete. Other drugs may interact with acetaminophen and aspirin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.