Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study
Alcohol use disorder (AUD) affects about 10 percent of people in the U.S. Studies show a relationship between the bacteria (microbiota) in the gut and the brain. Researchers think this may influence AUD. They want to learn more about changes in gut bacteria that may occur in people with AUD.
To study gut microbiota differences in current drinking versus abstinent people with AUD. Also to test if gut microbiota are related to alcohol cue-induced craving.
People ages 21-65 who have AUD (both abstinent and current heavy drinkers) or are healthy, moderate drinkers
Participants will be screened in Protocol 14-AA-0181.
Participants will have a first visit. They will have 4 more visits within about 10 days. Visits include:
Fecal sample collection
Assessment of diet and alcohol use
X-rays to test body composition,
They will sit under a ventilation hood to measure metabolism. They must fast 12 hours before this test.
They will drink a solution. Their urine is collected over 5 hours.
Ultrasound of the liver area. They must fast overnight before this test.