Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women
Brief Summary:
The purpose of this study is to determine whether low estrogen levels in young women with hypothalamic amenorrhea (premenopausal HypoE) is associated with risk factors for cardiovascular disease.
For this study, the investigators will measuring vascular function and immune markers on:
Premenopausal HypoE participants will then be randomized to use either an estrogen patch or a placebo patch (no active medicine) for 3 months, followed by estrogen or placebo patch plus progesterone or placebo pills for 2 additional weeks. The investigators are looking to see if estrogen improves vascular and immune function.