Clinical Trial: Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional




Official Title: Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

Brief Summary: This is a safety (Phase 1) trial using mebendazole for recurrent pediatric brain cancers that include medulloblastoma and high grade glioma, that are no longing responding to standard therapies. The drug mebendazole is an oral drug in a chewable 500 mg orange flavored tablet. It is already approved to treat parasitic infections. The purpose of this study is to determine the safety and side effects for increasing doses of mebendazole, followed by the treatment of an additional 12 patients at the best tolerated dose.