Clinical Trial: Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational




Official Title: Adiponectin, Interleukin-6 (IL-6) and High Sensitive C-reactive Protein (hsC-RP) in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Brief Summary: A high incidence of thromboembolic events has been observed in patients with β-thalassemia. Transfusion-related iron overload in β-thalassemia major(β-TM)has been associated with the onset of cardiovascular complications.It has previously found that both patients with β-TM and β-thalassemia intermedia(β-TI) have increased carotid intima-media thickness(cIMT) as compared with control healthy subjects.Vascular events appear at a relatively young age with a four times higher incidence in β-TI as compared with β-TM patients. Carotid intima-media thickness is related to incident and prevalent cardiovascular disease and is accepted measure of subclinical atherosclerosis. Lipid abnormalities have been detected in different types of β-thalassemia and patients with β-thalassemia are at risk of developing premature atherosclerosis because of those abnormalities .HsC-RP and IL-6 levels have been shown to correlate with endothelial dysfunction, arterial stiffness, and extent of subclinical atherosclerosis.IL-6 signaling has also been linked to plaque initiation and destabilization and to microvascular flow dysfunction. Studies had previously reported an inverse association between adiponectin level and C-RP. Adiponectin varies according to body mass index with lower levels in obese individuals,in type 2 diabetes mellitus and in hypertensive patients.Circulating low adiponectin levels has been correlated with elevated risk factors of atherosclerotic cardiovascular disease and associated with hypertension,dyslipidemia,and inflammation in both the general population and in diabetic patients.