Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: The Effects of Oral Nanocurcumin on Expression Levels of microRNA and Th17 Cells Development Factors in Ankylosing Spondylitis Patients
Brief Summary: Ankylosing spondylitis is a chronic autoimmune disease in which T cells associated with the disorder. The disease often affects the spine and hip bones. Inflammation involved in the area of the sacrum - Sacroiliac hip joints, pelvis, spinal lumbar, thoracic and cervical. Curcumin is a polyphenol. It is an active component of turmeric which is a perennial plant. Curcumin binding with a range of protein and the have ability to inhibit the activity of various kinases. Curcumin has a combination of activities such as antioxidant, anti-proliferation, anti-invasive, and can used in the treatment of Alzheimer's, Parkinson's, Multiple sclerosis, Cardiovascular disease, Bacterial diseases and Arthritis and ankylosing spondylitis. This increases the solubility of curcumin in nanomicelles spherical water to more than 100 thousand times, which significantly enhances the absorption of curcumin. A group of circulating miRNA in plasma is found to be the change they can be involved in inflammation or inhibit it. MiRNA expression profiles in blood and serum samples taken from patients with ankylosing spondylitis review that is miRNA-326 also affects cells of the immune system may be involved in disease ankylosing spondylitis. MiRNA-326 induces differentiation of Th17 cells via specific transcription factors, such as the RoRγt. MiRNA326 increased the expression of transcription factor RoRγt and Th17 cell differentiation TCD4 + cells resulting in the production of inflammatory cytokine IL17 increased inflammation and progression of inflammatory disease ankylosing spondylitis (AS).