Clinical Trial: In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional




Official Title: In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man

Brief Summary:

Working hypothesis: the interactions between the endogenous endocannabinoïds (ECS) - and cortisol, the end product of the Hypothalamo-Pituitary-Adrenal (HPA) axis may play a role in the pathophysiology of Cushing's syndrome.

The investigators speculate that:

  • acute or chronic variations in plasma cortisol may induce changes in the activity of the ECS
  • that there is a circadian rhythm of the ECS driven by the rythm of plasma cortisol