Clinical Trial: Comparison of Two Different Doses of Rabbit ATG-Fresenius With Cyclosporin in the Treatment of Acquired Aplastic Anaemia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional



Official Title: Protocol for Comparison of Two Different Regimens of Rabbit ATG-Fresenius With Cyclosporin in the Treatment of Acquired Aplastic Anaemia

Brief Summary:

Acquired Aplastic anemia is one of the most frequent reason of bone marrow failure in East (Pakistan).

  • The first treatment option is Allogenic Bone Marrow transplantation which is an expansive treatment option and also require a full matched HLA identical donor, hence hardly 25% of our affected patients get opportunity for BMT.
  • The second line treatment option caters a large chunk of patients (severe and non-severe AA) along with those who lack HLA identical donor.

Previously many protocols had been used in past for ATG+CsA Treatment, this treatment protocol especially addresses the two different regimens of ATG to study its efficacy, durability and long-term effects. Following doses would be used:

  • CsA+ATG @ 10mg/kg for 3 days
  • CsA+ATG @ 10mg/kg for 5 days