Clinical Trial: Natural History and Genetics of Food Allergy and Related Conditions
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Natural History and Genetics of Food Allergy and Related Conditions
Brief Summary:
Background:
- About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.
Objective:
- To learn more about the causes and effects of food allergy and related conditions.
Eligibility:
- People ages 2 99 who have food allergy and/or a related genetic or other condition
- Their relatives
- Healthy relatives and volunteers
Design:
- Participants will have at least 3 visits over 1 2 years, and then once a year for up to 12 years. Each may last a day or longer.
- Participants will be screened with medical history, physical exam, and questionnaires.
- Participants may have the following:
- Blood tests
- Allergy skin prick tests: Drops of allergens are placed on the back or arm. The skin is scratched under each drop.
- Leukapheresis: blood is taken from a needle in one arm, passed through a machine, and returned through a needle in the other arm.
- X-rays
- Esophageal string test: One end of a string is taped to the cheek and the other end is packed into a capsule. When the capsule is swallowed, the string unwinds; it is left in for at least 1 hour.
- EGD and colonoscopy: Biopsies ar