Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Effect of Cardiopulmonary Bypass on Serum CD39 and CD73 Level
Brief Summary:
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression. In recent previous studies, CD39 and CD73 was known to have important role in cancer patients for inducing immunosuppressive reaction and consequently induce cancer cell proliferation. However, the immunosuppressive effect of CD39 and CD73 during CPB time was not evaluated in previous studies.
The authors hypothesized that CD39 and CD73 would have important role in CPB induced immunosuppression. Therefore, the present study determined the effect of CD39 and CD73 during CPB.