Clinical Trial: Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional




Official Title: Saliva Cortisol Measurement for the Assessment of Hydrocortisone Replacement Therapy in Secondary Adrenal Insufficiency Patients

Brief Summary: Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution. Salivary cortisol is a good reflection of free plasmatic cortisol. However, salivary contamination with the oral intake of hydrocortisone has been described.
The aims of the study are to:
evaluate the frequency of salivary contamination by hydrocortisone taken in tablet form and determine its risk factors.
evaluate the quality of hydrocortisone substitution in patients with corticotrope deficiency.