Clinical Trial: New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis: Immunostimulation Plus Antibiotic Versus Immunosuppression Plus Antibiotic Versus Conventional Stand
Brief Summary:
- to investigate, whether one of the two alternative therapy strategies (antibiotic plus immunostimulation versus antibiotic plus immunosuppression) in chronic reactive arthritis is therapeutical superior to conventionel standardtherapy (DMARD).
- to investigate, whether one or more of the different therapy strategies cause an altered detection of bacterial DNA in the joint or colon.
- to measure the antigen-specific and -unspecific immune response (predominantly t-cell response) during therapy and correlate it with the clinical course.
- to gain knowledge from these analyses and the clinical course concerning the pathogenesis and the point of attack for possible therapies in chronic reactive arthritis.
- to compare cytokine-profiles of CD4- and CD8-positive T-cells from patients treated with infliximab to those treated with etanercept.