Clinical Trial: Xenodiagnosis After Antibiotic Treatment for Lyme Disease

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional




Official Title: Xenodiagnosis After Antibiotic Treatment for Lyme Disease - Phase II Study

Brief Summary:

Background:

The most common tick-borne illness in the United States, Lyme disease is caused by Borrelia burgdorferi bacteria that are transmitted to people by Ixodes scapularis ticks. Most cases of Lyme disease are cured by antibiotics, but some patients continue to experience symptoms despite the absence of detectable Lyme bacteria. Xenodiagnosis uses a vector to detect the presence of a disease-causing microbe.. Researchers will use live, laboratory-bred ticks to see if Lyme disease bacteria can be detected in people after completing antibiotic therapy and if that is more common in people who continue to experience symptoms such as fatigue and joint pain.

<TAB>

Objectives:

- To see if ticks can be used to detect B. burgdorferi in people who have had Lyme disease and received antibiotic therapy and if it correlates with persistent symptoms.

Eligibility:

  • Adults at least 18 years old who have:
  • Untreated erythema migrans (the Lyme disease rash); OR
  • Untreated Lyme arthritis; OR
  • Continuing symptoms after treatment for Lyme disease; OR
  • Had Lyme disease and antibiotic treatment within the past 12 months.
  • Healthy volunteers

Design:

  • Participants will be screened with medical history, physical exam, and blood tests.
  • Visit 1: