Study Status: NOT_YET_RECRUITING
Recruit Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Official Title: Hematuria Evaluation by Whole-genome Sequencing of Urine-Exfoliated Cell DNA, A Prospective, Multi-center Study
Brief Summary: Hematuria is recognized as an important sigh of potential urinary tract malignancy.
Therefore, understanding the disease processes and discovering the potential urothelial carcinoma (UC) underlying this important sign is critical.
Cystoscopy, urine cytology and imaging are most reliable methods for UC diagnosis, but certain drawbacks exist for these methods, such as invasiveness or inaccuracy.
Chromosomal instability (CIN) is a hallmark of human cancer, and it's related with tumor stage and grade.
Previous research has proved that analyzing CIN of the DNA extracted from urothelial cells in urine samples seems a promising method for detecting UC.
Here we intend to assess CIN's performance for hematuria evaluation.