Clinical Trial: Studies of Disorders With Increased Susceptibility to Fungal Infections

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational



Official Title: Studies of Disorders With Increased Susceptibility to Fungal Infections

Brief Summary:

Background:

- Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast. These disorders are often related to problems with the immune system and may have genetic factors, which suggests that researchers should study not only the individual with the disorder, but also his or her first- and second-degree relatives (such as parents, siblings, children, and first cousins). To provide material for future research, individuals with immune disorders and their first- and second-degree relatives will be asked to provide blood and other samples for testing and comparison with samples taken from healthy volunteers with no history of immune disorders.

Objectives:

- To collect blood and other biological samples to study immune disorders that make individuals more susceptible to fungal infections.

Eligibility:

  • Individuals of any age who have abnormal immune function characterized by recurrent or unusual fungal infections, recurrent or chronic inflammation, or other types of immune dysfunction.
  • First- or second-degree genetically related family members (limited to mother, father, siblings, grandparents, children, aunts, uncles, and first cousins).
  • Healthy volunteers at least 18 years of age (for comparison purposes).

Design:

  • Participants will provide blood samples and buccal (cells from the inside of the mouth near the cheek) samples.