Clinical Trial: Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type II Achalasia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

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Official Title: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-dose, Phase 2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IW-1701 in Pati

Brief Summary:

The objectives of this study are as follows:

In patients with primary Type II Achalasia, following a single 5-mg dose of IW-1701,

• To assess the safety and tolerability
• To determine the effects on measures of esophageal function by high-resolution impedance manometry (HRIM)
• To determine the pharmacokinetic (PK) parameters, Cmax, Tmax, and AUClast