Clinical Trial: Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX)

Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: INTERVENTIONAL




Official Title: Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Ri

Brief Summary: This prospective trial will randomize patients who have had an appendectomy to two different durations of antibiotic therapy depending on the status of the appendicitis.
For simple appendicitis, patients will be randomized to peri-operative antibiotics or 24 hours duration.
For complex appendicitis, patients will be randomized to 24 hours or 4 days duration.
Data will be collected prospectively and test the hypothesis that shorter durations of antibiotics will be non-inferior to the longer durations.