Clinical Trial: Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional




Official Title: Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features

Brief Summary: NSAIDs, specifically cyclo-oxygenase (COX) inhibitors, are known to increase blood pressure over time in non-pregnant adults, but the effect of COX-inhibitors on blood pressure in the setting of preeclampsia have not been well studied. This study aims to assess the effect of avoiding COX-inhibitors on postpartum blood pressure control among women diagnosed with preeclampsia with severe features. Eligible women will be randomized to receive either acetaminophen or ibuprofen for postpartum pain control. Both agents are first line therapies for pain control although ibuprofen has better pain control than acetaminophen. The primary outcome will be duration of postpartum severe-range hypertension.