Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Natural History and Immunopathogenesis of Stiff Person Syndrome (SPS)
Brief Summary:
This study will explore the role of various immune factors involved in producing the disease symptoms in stiff-person syndrome (SPS) and follow disease progression in patients. SPS is a progressive disease in which unexpected noises, touches or stressful events set off muscle spasms and stiffness. It is thought to be an autoimmune disease in which the body produces antibodies that attack certain healthy tissues. A better understanding of the disease may help researchers design new therapies.
Patients of any age with SPS may be eligible for this study, except those who:
Candidates will be screened with a medical history and physical and neurological examinations to confirm the diagnosis of SPS.
After screening, those enrolled in the study will be followed at the NIH Clinical Center every 6 months for 2 years (months 6, 12, 18, and 24) to have the following tests and procedures: