Clinical Trial: Fertility Assessment in Patients With Klinefelter Syndrome

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational



Official Title: Non-Invasive Methods to Maximize Fertility in Peri-Pubertal Patients With Klinefelter Syndrome

Brief Summary:

Klinefelter syndrome is characterized by primary testicular failure and progressive infertility. The objective of this study is to determine if sperm are present and can be observed in urine and semen samples of adolescent and young adult Klinefelter patients and to determine whether the presence of sperm correlates with physical and/or clinically obtained hormone measures of pubertal development.

This study was designed in order to answer the following questions:

  1. Is it possible to observe sperm in urine samples of adolescent and young adult Klinefelter patients?
  2. Is it possible to retrieve sperm for cryopreservation from semen samples of adolescent and young adult Klinefelter patients?
  3. Does the presence of sperm correlate with the physical and/or endocrine measures that are assessed during routine clinical evaluations of pubertal development in the KS patient population?
  4. If sperm retrieval is possible, what is the optimal age at which sperm retrieval should be attempted?