Clinical Trial: Sevoflurane and Laryngeal Reflex Responses in Pediatric Patients

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional




Official Title: Impact of High Concentrations of Sevoflurane on Laryngeal Reflex Responses in Pediatric Patients

Brief Summary: To describe laryngeal and respiratory reflex responses after controlled laryngeal stimulation in pediatric patients anesthetized with sevoflurane and to compare the evoked responses at two levels of anesthesia. To determine whether laryngeal and respiratory reflex responses after controlled laryngeal stimulation are completely suppressed in subjects when anesthetized with a MACEI95 (EI = endotracheal intubation) sevoflurane Hypothesis: The incidence of apnea with laryngospasm evoked by laryngeal stimulation will be reduced by 20% (from 25% to 5%) when the end-tidal concentration of sevoflurane is increased from 2.5% (MAC50) to 4.7% (MACEI95)