Clinical Trial: Natural History and Genetics of Food Allergy and Related Conditions

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational




Official Title: Natural History and Genetics of Food Allergy and Related Conditions

Brief Summary:

Background:

- About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.

Objective:

- To learn more about the causes and effects of food allergy and related conditions.

Eligibility:

  • People ages 2 99 who have food allergy and/or a related genetic or other condition
  • Their relatives
  • Healthy relatives and volunteers

Design:

  • Participants will have at least 3 visits over 1 2 years, and then once a year for up to 12 years. Each may last a day or longer.
  • Participants will be screened with medical history, physical exam, and questionnaires.
  • Participants may have the following:
  • Blood tests
  • Allergy skin prick tests: Drops of allergens are placed on the back or arm. The skin is scratched under each drop.
  • Leukapheresis: blood is taken from a needle in one arm, passed through a machine, and returned through a needle in the other arm.
  • X-rays
  • Esophageal string test: One end of a string is taped to the cheek and the other end is packed into a capsule. When the capsule is swallowed, the string unwinds; it is left in for at least 1 hour.
  • EGD and colonoscopy: Biopsies ar