Clinical Trial: Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
Brief Summary:
Background:
- Lymphatics are a type of vessel, similar to arteries and veins. Lymphatic disorders happen when these vessels don t work properly. Researchers want to look for a relationship between lymphatic disorders and variations of certain genes found in the lung, blood, and other places in the body.
Objective:
- To learn more about lymphatic disorders and evaluate how genetic factors affect lymphatic disorders.
Eligibility:
- People ages 2 90 who have a lymphatic disorder or relatives of people with lymphatic disorders.
- Healthy volunteers 18 and older.
Design:
- Participants may have 1 2 visits a year, or more as needed. The study is expected to last 5 years. Visits may last 1 5 days. Participants may have lab tests, medical history, and physical exam at each visit.
- Participants may have blood testing that includes genetics tests, and urine tests. They may have nose and throat cultures, saliva collection, and cheek swabs to collect samples.
- Participants may have a skin biopsy and have blood taken from an artery.
- Participants may have breathing tests and be studied while exercising.
- Participants may have an electrocardiogram. Electrodes will be placed on their chest, tracing heart rhythms. They may also have chest X-rays.
- Participants may have a bronchoscopy. A thin, flexible instrument will be passed t
