Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Invasive Hemodynamic Stress Test in Symptomatic and Asymptomatic Mitral Regurgitation
Brief Summary:
The preferred treatment of organic mitral regurgitation (MR) is mitral valve repair. Optimally this should be timed so late that it commensurate with the risk of surgery and before irreversibly damage of the heart and pulmonary vessels. The aim is to obtain an understanding of the differences between the symptomatic and asymptomatic patient.
The study will test
A: Symptomatic organic MR is characterized by higher filling pressure, and higher stroke work during physical strain compared with asymptomatic MR.
B: The extent of myocardial fibrosis is associated with filling pressure and cardiac index 1 year after mitral valve repair.
C: Filling pressure can be estimated non-invasively by echocardiography. To test this 40 patients with asymptomatic MR and 40 symptomatic will undergo a stress echocardiography with simultaneous echocardiography and invasive measurement of central hemodynamics. In addition a pulmonary function test and cardiac MRI will be performed.