Clinical Trial: Dynamic Monitoring of Circulating microRNA Changes in Patients With or Without Multiple Organ Failure

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational



Official Title: Dynamic Monitoring of Circulating microRNA Changes in Patients With or Without Multiple Organ Failure

Brief Summary:

The objectives are to:

  1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without multiple organ failure.
  2. investigate the dysregulation of circulating miRNA panel and their prognostic and predictive values in clinical outcomes in identifying patients at high risk for mortality and multiple organ failure.

This trial involves peripheral blood sampling from subjects at their earliest presentation and remaining stays in the hospitalization in the emergency department. The investigators will develop panels of miRNAs that are specific indicator of early onset of major organ failures, and correlate clinical outcomes with these miRNAs.