Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: An Adaptive Phase I/II Study to Assess Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of RO7112689 in Healthy Volunteers and Patients With Paroxysmal Nocturnal Hemoglobi
Brief Summary: This is a Phase I/II, first-in-human study consisting of 3 sequential parts in which the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single-doses of RO7112689 will be evaluated in healthy volunteers (HV) during Part I, and safety, tolerability, PK, PD, and efficacy of multiple-doses of RO7112689 will be evaluated in participants with paroxysmal nocturnal hemoglobinuria (PNH) during Parts 2 and 3 of the study.