Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: VRC 208: Phase 1/1b Open-Label Clinical Trial to Evaluate Dose, Safety and Immunogenicity of Recombinant Modified Vaccinia Virus Ankara Ebola Vaccine,VRC-EBOMVA079-00-VP, Administered Alone or as Boos
Brief Summary:
Background:
- Ebola virus is a rare disease that starts with fever and muscle aches, but can lead to death. The 2014 Ebola outbreak in West Africa is the largest to date. There are no approved treatments for Ebola. Researchers want to see if two new vaccines VRC-EBOMVA079-00-VP ( MVA-EbolaZ g) and VRC-EBOADC069-00VP ( cAd3-EBO ) are safe and able to induce an immune response against Ebola.
Objectives:
- To see if the two new vaccines are safe and if they cause any side effects. Also, to study immune responses to the vaccines.
Eligibility:
- Healthy adults ages 18-50.
Design: