Clinical Trial: Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational



Official Title: Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

Brief Summary:

Among the complications of heart transplant, primary dysfunction of the graft (PDG) is the most feared with a net impact on early morbidity and mortality. The all-cause mortality rate at the international level is 10% at 30 days and 34% at one year. Mortality at 30 days is secondary in 66% of cases with DPG or multi-organ failure.

The treatment of choice for the more severe PDG remains ECMO-type circulatory mechanical assistance or ventricular assistance. According to several studies, this could reduce early mortality. Early placement and short-term (<30 days) of support appear to improve survival in the first year after transplantation.

The haemodynamic parameters revealing this DPG are not clearly described in the literature.

hypothesis of this research is that:

  • DPG risk factors in strasbourg's hospital center are comparable to other European and international centers.
  • Simple hemodynamic parameters can be used to detect PDG earlier in order to set up assistance more quickly.
  • DPG risk factors in investigator's center are comparable to other European and international centers.
  • Simple hemodynamic parameters can be used to detect DPG earlier in order to set up assistance faster