Clinical Trial: An Imaging Study Using PET/CT to Characterize the Effect of Intravenous Reslizumab on Airway Inflammation

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional




Official Title: Distribution of Eosinophils in Asthma After Reslizumab (DEAR). A 7-week, Placebo- Controlled, Double-Blinded, Parallel-Group, Imaging Study Using Positron Emission Tomography/Computed Tomography (PET/

Brief Summary: This is an exploratory study with the primary objectives to 1) establish that PET/CT of the lung can reliably distinguish healthy, non-asthmatic volunteers from patients with asthma and an eosinophilic phenotype and 2) to examine the utility of PET/CT for demonstrating that reslizumab produces a reduction in lung inflammation in patients with severe asthma and an eosinophilic phenotype .