Clinical Trial: RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational



Official Title: Comparison of Right Ventricular Septal Pacing to Minimized Right Ventricular Septal Stimulation in Patients With Sick Sinus Syndrome

Brief Summary:

Background:

  • Potential negative effects of pacing in the RV-apex are well documented
  • However, study results comparing septal / RVOT-pacing versus RV-apical pacing controversial.
  • The optimal pacing mode in SSS (DDDR versus AAIR) is unclear, as the DDD (R) mode with an AV delay ≤ 220 ms should be the preferred pacing mode, according to the DANPACE trial [DANPACE, ESC 2010, Stockholm].

Aim:

- to evaluate chronic effects of proven right ventricular septal compared to minimized right ventricular septal pacing in patients with SSS

Inclusion criterion:

-Pacemaker indication according to current guidelines: sick sinus syndrome (SSS)

Exclusion criteria:

  • Life expectancy < 2 years
  • Age <18 years
  • Noncompliance with regard to participation in the study
  • Pregnancy
  • AV block ° 2 and higher
  • Permanent atrial fibrillation
  • Heart failure NYHA III and IV, reduced LV-EF <40%
  • ICD indication
  • Acute coronary syndrome. PCI or CABG <3 months
  • Heart transplant
  • Placement of septal RV electrode is not possible

Study design: